| 2024 | Jacques, C., Marchand, F., Chatelais, M., Floris, I. | Journal of Inflammation Research | Actives from the Micro-Immunotherapy Medicine 2LMIREG® Reduce the Expression of Cytokines and Immune-Related Markers Including Interleukin-2 and HLA-II While Modulating Oxidative Stress and Mitochondrial Function | |
| 2024 | Ferrà-Cañellas, MDM., Garcia-Sureda, L. | Life (Basel) | Exploring the Potential of Micro-Immunotherapy in the Treatment of Periodontitis | |
| 2024 | Jacques, C., Marchand, F., Chatelais, M., Brulefert A., Riffault, M., Floris, I. | Life (Basel) | In Vitro Study of Interleukin-6 when Used at Low Dose and Ultra-Low Dose in Micro-Immunotherapy | |
| 2024 | Jacques, C., Marchand, F. Chatelais, M., Albinet, V., Coustal, C., Floris, I. | Cancers | The Micro-Immunotherapy Medicine 2LPAPI® Displays Immune-Modulatory Effects in a Model of Human Papillomavirus Type-16 L1-Protein Capsid-Treated Human Peripheral Blood Mononuclear Cells and Antiproliferative Effects in a Model of Cervical Cancer Cells | |
| 2024 | Jacques, C., Marchand, F., Chatelais, M., Brulefert, A., Floris, I. | Life | Understanding the Mode of Action of a Micro-Immunotherapy Formulation: Pre-Clinical Evidence from the Study of 2LEBV® Active Ingredients | |
| 2023 | Ferrà, M., Munar, M., Floris, I., Ramis, J.M., Monjo, M., García, L. | International Journal of Molecular Sciences | A Sequential Micro-Immunotherapy Medicine Increases Collagen Deposition in Human Gingival Fibroblasts and in an Engineered 3D Gingival Model under Inflammatory Conditions | |
| 2023 | Jacques, C., Floris, I. | International Journal of Molecular Sciences | How an Immune-Factor-Based Formulation of Micro-Immunotherapy Could Interfere with the Physiological Processes Involved in the Atopic March | |
| 2023 | Jacques, C., Floris, I. | Journal of Inflammation Reasearch | Special Focus on the Cellular Anti-Inflammatory Effects of Several Micro-Immunotherapy Formulations: Considerations Regarding Intestinal-, Immune-Axis-Related- and Neuronal-Inflammation Contexts | |
| 2022 | Jacques, C., Chatelais, M., Fekir, K., Brulefert, A., Floris, I. | International Journal of Molecular Sciences | The Unitary Micro-Immunotherapy Medicine Interferon-y (4 CH) Displays Similar Immunostimulatory and Immunomodulatory Effects than Those of Biologically Active Human Interferon-? on Various Cell Types | |
| 2022 | Jacques, C., Marchesi, I., Fiorentino, F. P., Chatelais, M., Libera, N., Appel, K., Lejeune, B., Floris, I. | International Journal of Molecular Sciences | A Micro-Immunotherapy Sequential Medicine MIM-seq Displays Immunomodulatory Effects on Human Macrophages and Anti-Tumor Properties towards In Vitro 2D and 3D Models of Colon Carcinoma and in an In Vivo Subcutaneous Xenograft Colon Carcinoma Model | |
| 2021 | Jacques, C., Chatelais, M., Fekir, K., Fauconnier, L., Mellier, M., Togbe, D., Floris, I. | International Journal of Molecular Sciences | The Micro-Immunotherapy Medicine 2LEID Exhibits an Immunostimulant Effect by Boosting Both Innate and Adaptive Immune Responses | |
| 2021 | Jacques, C., Lejeune, B., Floris, I. | International Journal of Molecular Sciences | Ultra-Low Dose Cytokines in Rheumatoid Arthritis, Three Birds with One Stone as the Rationale of the 2LARTH® Micro-Immunotherapy Treatment | |
| 2020 | Ferrà, M., Munar, M. García, L. Lejeune, B. Ramis, J.M., Monjo, M. | Journal of Periodontology | BMP4 micro-immunotherapy increases collagen deposition and reduces PGE2 release in human gingival fibroblasts and increases tissue viability of engineered 3D gingiva under inflammatory conditions | |
| 2020 | Floris, I., García-González, V., Palomares, B., Appel, K., Lejeune, B. | International Journal of Rheumatology | The Micro-Immunotherapy Medicine 2LARTH® Reduces Inflammation and Symptoms of Rheumatoid Arthritis In Vivo | |
| 2020 | Floris, I., Chenuet P., Togbe D., Volteau C., Lejeune B. | Dose Response Journal | Potential Role of the Micro-Immunotherapy Medicine 2LALERG® in the Treatment of Pollen-Induced Allergic Inflammation | |
| 2020 | Floris, I., Rose, T., Collado, J.A., Appel, K, Roesch, C., Lejeune, B. | Dose Response Journal | Pro-Inflamatory Cytokines at Ultra-Low Dose Exert Anti-Inflammatory Effect In Vitro: A Possible Mode of Action Involving Sub-Micron Particles? | |
| 2019 | Lilli, N., Révy, D., Robelet, S., Lejeune, B. | Degenerative Neurological and Neuromuscular Disease – Dove Press journal | Effect of the micro-immunotherapy medicine 2LPARK® on rat primary dopaminergic neurons after 6-OHDA injury: oxidative stress and survival evaluation in an in vitro model of Parkinson’s disease | |
| 2019 | Lilli, N., Révy, D., Volteau, C., Robelet, S., Lejeune, B. | Biomedical & Life Sciences Journal | Effect of 2LMISEN® on Long-Term Hippocampal Neurons Culture as a Screening Senescent Cells Model: p16INK4A and Caspase 3 Quantification | |
| 2018 | Floris, I., Lechner, J., Lejeune, B. | Journal of Biological Regulators & Homeostatic Agents | Follow-up of patients with systemic immunological diseases undergoing fatty-degenerative osteolysis of the jawbone surgery and treated with RANTES 27CH | |
| 2018 | Floris, I., Appel, K., Thorsten, R., Lejeune, B. | Journal of Inflammation Research | 2LARTH®, a micro-immunotherapy medicine exerts anti-inflammatory effects in vitro and reduces TNF-alpha and IL-1beta secretion | |
| 2018 | Mancini, F., Milardi, D., Carfagna, P., Grande, G., Miranda, V., De Cicco, A., Ricciardi, D., Pontecorvi, A., Marana, R., De Cicco, F. | International Immunopharmacology | Low-dose SKA Progesterone and Interleukin-10 modulate the inflammatory pathway in endometriotic cell lines | |
| 2017 | Marin-Martin, L.S., Giovannangeli, F., Bizzi, E., Massafra, U., Ballanti, E., Cassol, M., Migliore, A. | GDrug Des Devel Ther | An open randomized active-controlled clinical trial with low dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis | |
| 2017 | Tessaro, I., Modina, S., Lodde, V., Sivelli., Franciosi, F., Terzachi, L., Luchini, P., Rumio, C., Luciano, A. | Journal of Reproductive Infertility | Ultra-Low Dose of Follicle Stimulating Hormone and Progesterone Attenuate the Severity of Polycystic Ovary Syndrome Features in a Hyperandrogenized Mouse Model | |
| 2017 | Uberti, F., Bardelli, C., Morsanuto, V., Ghirlanda, S., Cochis A., Molinari, C. | Cells, Tissues, Organs | Stimulation of the Nonneuronal Cholinergic System by Highly Diluted Acetylcholine in Keratinocytes | |
| 2016 | Camps, A., Almolda, B., Gonzalez, B., Castellano, B. | Homeopathy | Microimmunotherapeutic administration of cytokines improve the clinical symptoms in EAE an animal model of multiple sclerosis | |
| 2016 | Barygina, V., Becatti, M., Lotti, T., Moretti, S., Taddei N., Fiorillo, C. | Journal of Dermatological Science | Low dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients | |
| 2016 | Fiorito, F., Cantiello, A., Granato, G.E., Navas, L., Diffidenti, C., De Martino, L., Maharajan, V., Olivieri, F., Pagnini, U., Lovane, G. | Comp Immunol microbiol Infect Dis. | Clinical improvement in feline herpesvirus 1 infected cats by oral low dose of interleukin-12 plus interferon-gamma | |
| 2016 | Thomas, G., Cluzel, H., Lafon, J., Bruhwyl, J., Lejeune, B. | Advances in Infectious Diseases | Efficacy of 2LPAPI®, a Micro-Immunotherapy Drug, in Patients with High-Risk Papillomavirus Genital Infection | |
| 2015 | Barygina, V., Becatti, M., Lotti, T., Moretti, S., Taddei N., Fiorillo, C. | Journal of Dermatological Science | Treatment with low-dese cytokines reduces oxidative-mediated injury in perilesional keratinocytes from vitiligo skin | |
| 2015 | Lotti, T., Hercogovo, J., Wollina, U., Chokoeva, A.A., Zarrab, Z., Gianfaldoni, S., Roccia, M.G., Fioranelli, M., Tchernev, G. | J Biol Regul Homeost Agents | Vitiligo: successful combination treatment based on oral low dose cytokes and different topical treatments | |
| 2015 | Radice, E., Bellone, G., Miranda, V. | Translational Oncology | Enhancement of the Immunostimulatory Functions of Ex Vivo–Generated Dendritic Cells from Early-Stage Colon Cancer Patients by Consecutive Exposure to Low Doses of Sequential-Kinetic-Activated IL-4 and IL-12. A Preliminary Study | |
| 2013 | Cardani, D., Dusio, G., Luchini , P., Sciarabba, M., Solimene, U., Rumio, C. | Gastroenterology Research | Oral Administration of Interleukin-10 and Anti-IL-1 Antibody Ameliorates Experimental Intestinal Inflammation | |
| 2012 | D’Amico, L., Ruffini, E., Ferracini, R., Roato, I. | Journal of Cancer Therapy | Low Dose of IL-12 Stimulates T Cell Response in Culters of PBMCs Derived from Non Small Cell Lung Cancer Patients | |
| 2012 | Mazzoli, S., Cai, T., Meacci, F., Addonisio, P., Dorfman, P. | International Journal of High Dilution Research | High Risk Human Papillomavirus genital infections in asymptomatic population: effectiveness of Micro-Immunotherapy | |
| 2011 | Van der Brempt, X., Cumps, J., Capieaux, E. | Revue Française d’Allergologie | Clinical efficacy of 2LALERG®, a new sublingual immunomodulatory treatment, in seasonal allergic rhinitis: A double-blind placebo-controlled study | |
| 2009 | Gariboldi, S., Palazzo, M., Zanobbio, L., Dusio, G., Mauro, V., Solimene, U., Cardani, D., Mantovani, M., Rumio, C. | Pulmonary Pharmacology & Therapeutics | Low dose oral administration of cytokines for treatment of allergic asthma | |
| 2000 | Jenaer, M., Henry, MF., García, A., Marichal, B. | British Homeopathic Journal | Evaluation of 2LHERP® in preventing recurrences of genital herpes | |
| | | | |
| | | | |
